Contraindicated. CYP3A4 is to blame for the development and elimination of cariprazine's Energetic metabolites. The impact of CYP3A4 inducers on cariprazine exposure has not been evaluated and also the net effect is unclear.pentobarbital will decrease the level or influence of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minim

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